Revolution Plus vs. Nexgard Combo – Which One is Suitable for Your Cat?

By | March 27, 2026
revolution Plus vs Nexgard Combo

Parenting a cat is a life-changing experience. The little fur balls come into our lives and fill them with love and happiness. However, taking care of a cat is not an easy task, as a lot of hard work is needed to ensure their good health and protect them from internal and external parasites. Thankfully, there is a wide range of options available on the market indicated to protect cats from major types of parasites. However, the plethora of options can tend to overwhelm and confuse you. But we’re here to help!

In this blog, we will compare two of the most popular parasitic treatments for cats – Revolution Plus and NexGard Combo. We will also discuss their key features, parasitic coverage, similarities, and differences to help you decide on a suitable treatment for your cat.

Let’s get started!

Revolution Plus & NexGard Combo – An Overview

Let’s take a quick glance at Revolution Plus and NexGard Combo.

Revolution Plus

Revolution Plus for Cats is a topical treatment for cats indicated for the prevention of heartworm disease caused by Dirofilaria immitis. It also treats and controls roundworms and intestinal hookworm infections and aids in the treatment and control of ear mite infestations. The formula further kills adult fleas and treats and prevents flea infestations. It also helps prevents tapeworm infections by killing Ctenocephalides felis (vector fleas)on the treated cat. Additionally, the product treats and controls tick infestations caused by lone star ticks, Gulf Coast ticks, American dog ticks, and black-legged ticks. Revolution Plus is designed for monthly administration and is suitable for cats and kittens from 8 weeks of age, weighing at least 2.8 lbs.

NexGard Combo

The topical formula of NexGard Combo for Cats is designed for cats and indicated for the prevention of heartworm disease caused by Dirofilaria immitis. The treatment also helps in the treatment and control of roundworms, hookworms, and tapeworms. It further kills adult fleas and treats and prevents flea infestations. Additionally, the treatment aids in the treatment and control of tick infestations caused by black-legged ticks and lone star ticks. It is a monthly treatment and caters to cats and kittens from 8 weeks of age, weighing at least 1.8 lbs.

Similarities & Differences

The following are the similarities and differences between Revolution Plus and NexGard Combo.

The Similarities

  • Both Revolution Plus and NexGard Combo are available as topical formulas, designed for monthly administration.
  • Both treatments are designed to protect cats against heartworm disease caused by Dirofilaria immitis.
  • Both of them are effective against intestinal worms like roundworms, hookworms, and tapeworms.
  • Both products kill adult fleas and treat and prevent flea infestations.
  • Both Revolution Plus and NexGard Combo treat and control tick infestation caused by black-legged ticks and lone star ticks.
  • Both products are suitable for cats and kittens from 8 weeks of age.
  • The safe use of both Revolution Plus and NexGard Combo has not been evaluated in breeding, pregnant, or lactating cats

The Differences

  • While Revolution Plus treats and controls tick infestations caused by Gulf Coast ticks and American dog ticks, NexGard Combo doesn’t.
  • Revolution Plus treats and controls ear mite infestations. NexGard Combo has no such claim.
  • Revolution Plus helps prevent tapeworm infections by killing Ctenocephalides felis (vector fleas)on treated cat. But NexGard Combo doesn’t.
  • Revolution Plus is composed of Selamectin and Sarolaner as its active ingredients. However, NexGard Combo features Esafoxolaner, Eprinomectin, and Praziquantel as its active ingredients.
  • While Revolution Plus is suitable for cats and kittens from 2.8 lbs, NexGard Combo caters to felines from 1.8 lbs.

A Detailed Analysis

Let’s take a look at the detailed comparison between the key features of Revolution Plus and NexGard Combo.

Revolution Plus and NexGard Combo Features

Frequently Asked Questions

Which treatment is better for protection against ticks? Revolution Plus or NexGard Combo?

Both Revolution Plus and NexGard Combo are highly effective against ticks. However, while Revolution Plus is effective against lone star ticks, Gulf Coast ticks, American dog ticks, and black-legged ticks, NexGard Combo offers coverage against black-legged ticks and lone star ticks.

Are Revolution Plus and NexGard Combo suitable for indoor cats?

Despite not going outside, indoor cats are still at risk of parasites brought in by humans or other pets, making monthly prevention essential. Both Revolution Plus and NexGard Combo are highly suitable and recommended for parasite prevention in indoor cats.

Can I use both Revolution Plus and NexGard Combo at the same time?

Revolution Plus and NexGard Combo shouldn’t be used at the same time, as combining them could lead to an overdose of similar active ingredients.

Are Revolution Plus and NexGard Combo safe for kittens?

Revolution Plus and NexGard Combo are safe for kittens from 8 weeks of age. Prior to administering any of the products, make sure your cat meets the minimum weight requirements specified on the product labels.

Ending Note

Revolution Plus and NexGard Combo are vet-recommended topical treatments for cats effective against several species of internal and external parasites. However, the products differ when it comes to composition, parasitic coverage, and weight criteria.

If you want coverage against heartworm disease, fleas, tick species like black-legged ticks and lone star ticks, as well as roundworms, hookworms, and tapeworms, you can go for any of the treatments. However, if you’re looking for coverage against tick species like Gulf Coast ticks and American dog ticks, as well as ear mites, you should opt for Revolution Plus. However, you must ensure that your cat meets the minimum age and weight requirements specified on the product labels.

Both Revolution Plus and NexGard Combo are available on BestVetCare at discounted prices. Check out our online store today to shop your preferred products from the comfort of your home.