Fleas are a daunting threat for dogs and protecting them against these nasty parasites is of utmost importance. It is good to have loads of options available for a flea treatment, but making the best choice for your canine friend is always challenging for the pet parents. To help you find an effective treatment for your furry companion, we have listed two of the best flea products – Simparica TRIO and Comfortis Plus.
This blog explains in detail about these products, including their features, key benefits, and key differences. Both these products are high in demand and strongly favored by pet parents. Read through the blog to understand the effectiveness of these treatments and to choose the best option for your pet.
Let’s start by comparing their unique features.
Comparing Simparica TRIO and Comfortis Plus

About Simparica TRIO and Comfortis Plus
Simparica TRIO is a liver-flavored tasty chew that protects from both internal and external parasites for a month. It is suitable for use in dogs and puppies aged 8 weeks and above, or weighing 2.8 lbs or more.
Comfortis Plus is a palatable, beef-flavored chewable table that provides protection against fleas, heartworm disease, and intestinal worms for one month. This formula is safe for use in dogs and puppies of 8 weeks and older or having a weight of 5 lbs and more.
Both the products have different pack sizes based on the weight and size of the dog.
Next, we will see a few similarities between the two flea treatments.
Similarities – Simparica TRIO and Comfortis Plus
Both have a few common key benefits. The similar features between the two are:
Palatable Taste:
Simparica TRIO and Comfortis Plus both come in a flavorful chewable tablet form. These monthly treatments protect dogs and puppies against fleas.
Flea Protection:
Both kill adult fleas and are effective treatments and prevent flea infestations in dogs.
Administration:
Both are oral treatments given every month. Simparica TRIO and Comfortis Plus can be administered with or without food, and it is recommended to be done with food for maximum efficiency. The chews can also be given as a treat.
No Waiting:
Both treatments – can be initiated in any season or time of the year and must be continued throughout the year for effective results. Take your vet’s advice on what treatment to start depending on the breed, age, size, and weight of your dog.
Animal Safety:
The suitability of both the products in breeding, pregnant or lactating dogs has not been evaluated or researched.
It is not safe to use Simparica TRIO and Comfortis Plus in breeding, pregnant or lactating dogs.
Also Read: Popular Flea and Tick Treatments for Dogs In 2023
Differences – Simparica TRIO and Comfortis Plus
The following are key differentiators between these well-liked treatments:
Minimum Age
Simparica TRIO – The vet’s recommendation is to use it for dogs and puppies 8 weeks and older or weighing 2.8 lbs or more.
Comfortis Plus – Is safe to use for dogs and puppies aged 8 weeks and above or weighing 5 lbs and more.
The composition
Simparica TRIO – As the name indicates, it is a combination of 3 active ingredients, namely Sarolaner, Moxidectin, and Pyrantel.
Comfortis Plus – This formulation comprises Spinosad and Milbemycin Oxime as its active ingredients.
Protection against Ticks
Simparica TRIO – Treats and controls 5 varieties of ticks including Lone Star ticks, American dog ticks, Black-legged ticks, and Brown dog ticks.
Comfortis Plus – It does not kill or protect against ticks. It is a monthly flea treatment.
Effectiveness
Simparica TRIO – Starts killing fleas within 4 hours of administration and is 100% effective in 8 hours.
Comfortis Plus – Actively begins killing fleas within 30 minutes of oral administration and destroys 100% of fleas within 4 hours of dosing.
The comparison table below helps us better understand Simparica TRIO Vs. Comfortis Plus:

Final Notes
Now, with all the details explained you can make an appropriate choice between the two flea treatments. Both products kill fleas and prevent flea infestation, heartworm disease, and intestinal worms. While Simparica TRIO protects against 5 types of ticks, Comfortis Plus is not a tick treatment. Comfortis Plus has quick action and starts giving results within 30 minutes of dosing, while Simparica TRIO works within 4 hours of dosing. Choosing between the two products depends on your dog’s specific needs and the parasitic treatment you are targeting. However, always consult your dog’s vet before commencing any of these treatments.