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Heartgard Plus for Dogs

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4.6/5
(521)

Starts From:

$40.51

Nuheart (Generic Heartgard) Small Dogs upto 25lbs (Blue)

Pack
Qty
Price
 
6 Tablet
$24.64
12 Tablet
$41.47

Heartgard Plus Chewables Small Dogs up to 25lbs (Blue)

Pack
Qty
Price
 
6 Doses (Exp: June 2026)
$40.51

Nuheart (Generic Heartgard) Medium Dogs 26-50lbs (Green)

Pack
Qty
Price
 
6 Tablet
$25.63
12 Tablet
$46.42

Nuheart (Generic Heartgard) for Large Dogs 51-100lbs (Red)

Pack
Qty
Price
 
6 Tablet
$26.62
12 Tablet
$50.38

Heartgard Plus Chewables for Medium Dogs 26-50lbs (Green)

Pack
Qty
Price
 
6 Doses
$42.65

Heartgard Plus Chewables for Large Dog 51-100lbs (Brown)

Pack
Qty
Price
 
6 Doses
$58.87
  • Information
  • Key Benefits
  • Directions for Use
  • Safety
  • FAQ
Information

Heartgard Plus Chews for Dogs

Heartgard Plus helps you shield your dog from the threat of heartworm disease. This disease is caused by a bite from an infected mosquito and is prevalent in all 50 states. So, no matter the part of the country you live in, your vet would want you to use a heartworm preventive for your dog’s protection. This real-beef chew is a vet-recommended and #1 dog-preferred heartworm preventive for dogs aged 6 weeks and above as per the manufacturer studies. This versatile chew also treats and controls 3 species of hookworms and 2 species of roundworms. It is available in three different packs for accurate dosage in dogs of different weights.

Heartgard Plus coverage

You may start with your dog’s heartworm protection with Heartgard Plus during the period of the year when mosquitoes, potentially carrying infective heartworm larvae, are active. It eliminates the tissue stage of heartworm larvae and prevents canine heartworm disease. This monthly heartworm chew also works as a roundworm and hookworm treatment for dogs. When given at monthly intervals, Heartgard Plus helps provide year-round protection against parasites to support your dog’s overall well-being.

How does Heartgard Plus work?

Heartgard Plus is made with a combination of two ingredients: ivermectin and pyrantel. When administered as recommended, ivermectin allows the immune system to recognize and inactivate heartworm larvae before they develop into adults and prevent heartworm disease as a result. The pyrantel in this monthly chew treats and controls hookworms and roundworms.

Ingredients

Heartgard Plus Ingredients: Ivermectin and Pyrantel

Nuheart Ingredient: Ivermectin

Key Benefits
Advantages Of Heartgard Plus
  • Easy-to-dose, oral heartworm preventive for dogs
  • Offers a palatable real-beef flavor
  • No.1 dog-preferred chew, as per the manufacturer studies
  • Vet-recommended
  • Prevents canine heartworm disease
  • Treats and controls 2 species of roundworms and 3 species of hookworms
  • Protects for one whole month
  • Can be given to dogs from 6 weeks of age
  • Available in different weight-specific dosage packs
Directions for Use

Instructions To Use Heartgard Plus

  • Weigh your dog and get the suitable pack of Heartgard Plus Chews.
  • Remove one chewable from the foil-backed blister card.
  • Offer the chew to your dog by hand.
  • Encourage your dog to chew it rather than swallow it without chewing.
  • You may also break the chew into pieces and feed it.
  • Alternatively, it can be added intact to a small amount of dog food to encourage chewing.
  • Observe your pet for several minutes to ensure they consume the complete dose at one time.
  • If you suspect that the dose has been lost, re-dosing is recommended.
  • Give the chew once a month on or about the same day of the month.
  • When replacing another heartworm preventive, give the first dose of Heartgard Plus within 30 days of the last dose of the former preventive.

Packaging:

  • Heartgard Plus Chews are available in three different packs for convenient, weight-appropriate dosage.
  • The packs are color-coded for easier identification.

Dosing Schedule:

Dog weight

Dog size

Pack color

Ivermectin content

Pyrantel content

Chewables per month

0 to 25 lbs.

Small

Blue

68 mcg

57 mg

1

26 to 50 lbs.

Medium

Green

136 mcg

114 mg

1

51 to 100 lbs.

Large

Brown

272 mcg

227 mg

1

Over 100 lbs.

Administer the appropriate combination of chewables

Safety
Heartgard Plus Safety Measures
  • This chew is not for human use. Use it only for your dog.
  • It should be kept out of reach of children.
  • If an accidental ingestion by humans happens, immediately consult a physician.
  • Store Heartgard Plus in a secure location, away from pets, to prevent accidental ingestion or overdose.

Precautions

  • The dog should be tested for existing heartworm infection before starting to use Heartgard Plus.
  • It is not effective against adult heartworms, so infected dogs must be treated to remove the adult heartworms and microfilariae before giving Heartgard Plus.

Storage

  • Store between 68°F - 77°F (20°C - 25°C). Excursions between 59°F - 86°F (15°C - 30°C).
  • Protect from light.
FAQ

Is it safe to give my dog Heartgard Chews?

Heartgard Plus is a vet-recommended and #1 dog-preferred heartworm preventive, as per the manufacturer studies. When used as recommended, it has been shown to be safe in pregnant or breeding dogs, stud dogs, and puppies aged 6 or more weeks.

Can I give Heartgard chews to my dog along with other medications?

Studies suggest that Heartgard Plus may be used with commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, and vaccines.

Do I have to give Heartgard Plus to my dog even when the weather is cold?

Heartworm transmission may decrease in colder months, but the risk is never zero. Besides, on-again, off-again heartworm disease protection can leave gaps in protection and can make your dog vulnerable to heartworm disease. It is recommended to keep your dog on a year-round heartworm prevention plan.  

When can I start giving Heartgard Plus to my dog?

The initial dose of Heartgard Plus must be given within a month (30 days) after the dog’s first exposure to mosquitoes. When you are replacing another heartworm preventive with Heartgard Plus, the first dose of this chew must be given within a month (30 days) of the last dose of the former preventive.

What to do if I miss a dose of Heartgard Plus?

If the dosage of Heartgard Plus is delayed by a few days or longer, immediate administration of Heartgard Plus and resumption of the recommended dosing regimen helps minimize the chances of the development of adult heartworms. If in doubt, consult a veterinarian for guidance.

Does Heartgard Plus prevent parasites other than heartworms?

Heartgard Plus treats and controls 2 species of roundworms and 3 species of hookworms in addition to preventing heartworm disease.

Should I get my dog tested for heartworms before using Heartgard Plus?

Heartgard Plus is not effective against adult D. immitis (heartworms). It is therefore necessary that dogs are tested for heartworms before using it. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a preventive program with Heartgard Plus.

How do I get Heartgard Plus for my dog?

You can shop for this widely trusted heartworm preventive online.

Customer Review
Overall Rating

Star4.6/5

521 reviews
521 reviews
Sort By:
Patricia
Good prices

No problems at all. Good prices on heartguard and nexguard

Feb 26, 2026
William
Reliable option

Best prices and reliable service!

Feb 24, 2026
RENEE
Love it.

Price is reasonable. Fast shipping and I love it.

Feb 13, 2026
Harrison
Best Pricing

The pricing of this website is very affordable.

Feb 08, 2026
Henny
Works Wonders

No more stressed about heartwom disease

Feb 01, 2026
Have A Question?
Question:
Q:

What's the difference between the tablets and doses besides pricing?

Answer:
A:

'Doses' reflect the number of Heartgard Plus chews you will receive. For example, if you order '6 Doses', you will receive 6 Heartgard Plus chews, each of which will last for one month.

Nov 11, 2025
Question:
Q:

what is differnence with Heathguard plus and the generic nuheart? does generic control the worms like heartguard plus

Answer:
A:

Heartgard Plus contains ivermectin and pyrantel as active ingredients. As a result, it prevents heartworm disease and treats and controls hookworms and roundworms. Generic Nuheart contains ivermectin as the active ingredient; hence, it only prevents heartworm disease in dogs.

Jun 17, 2025
Question:
Q:

How long does it take to ship to United States?

Answer:
A:

All orders are processed and dispatched on the same day. Orders received on a public holiday/weekend are dispatched on the next working day. Our standard delivery time is between 10-15 working days.

Mar 03, 2025
Question:
Q:

Is this also flea and tick prevention?

Answer:
A:

Heartgard Plus helps prevent heartworm disease. It also protects against roundworm and hookworm infections.

Feb 07, 2025
Question:
Q:

what color is the pill for the large dogs. I bought 2 different weights and not sure which is which

Answer:
A:

Heartgard Plus for Small Dogs up to 25lbs comes in a blue pack, for Medium Dogs 26-50lbs comes in the green pack and for Large Dogs 51-100lbs comes in the brown pack.

Dec 30, 2024
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