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Simparica TRIO for Dogs

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4.7/5
(454)

Starts From:

$51.37

Simparica TRIO for Dogs 2.8-5.5 lbs (Yellow)

Pack
Qty
Price
 
3 Doses
$51.37
6 Doses
$88.00

Simparica TRIO for Dogs 5.6-11 lbs (Purple)

Pack
Qty
Price
 
3 Doses
$52.36
6 Doses
$91.96
12 Doses
$171.16

Simparica TRIO for Dogs 11.1-22 lbs (Caramel)

Pack
Qty
Price
 
3 Doses
$58.30
6 Doses
$97.90
12 Doses
$192.94

Simparica TRIO for Dogs 22.1-44 lbs (Blue)

Pack
Qty
Price
 
3 Doses
$61.27
6 Doses
$109.78
12 Doses
$209.77

Simparica TRIO for Dogs 44.1-88 lbs (Green)

Pack
Qty
Price
 
3 Doses
$64.24
6 Doses
$113.74
12 Doses
$212.74

Simparica TRIO for Dogs above 88 lbs (Brown)

Pack
Qty
Price
 
3 Doses
$69.19
6 Doses
$123.64
12 Doses
$224.62
  • Information
  • Key Benefits
  • Directions for Use
  • Safety
  • FAQ
Information

Simparica TRIO Chews for Dogs

Simparica TRIO is a widely prescribed, broad-spectrum parasite preventive for your dog. According to Zoetis, this versatile treatment has protected million of dogs so far. It is flavored to make the dosing easier; dogs love the taste and readily accept this chew. This delicious chew provides triple protection to your dog against heartworm disease, ticks & fleas, and worms (roundworms and hookworms). This monthly treatment is suitable for dogs aged 8 weeks and above, and weighing at least 2.8 pounds. Simparica TRIO is available in different flavored tablet sizes for accurate dosage in dogs of different weights.

Simparica TRIO coverage

Simparica TRIO chews are to be administered at monthly intervals. You may start your dog’s treatment with this chew at any time of the year. When administered as recommended, Simparica TRIO prevents heartworm disease caused by Dirofilaria immitis, and treats and controls roundworm and hookworm infections. It kills adult fleas, prevents flea infestations, and treats and controls tick infestations with lone star tick, Gulf Coast tick, American dog tick, black-legged tick, brown dog tick, and Asian longhorned tick.

Additionally, this all-inclusive treatment helps prevent flea tapeworm infections as a direct result of killing fleas, and helps reduce the risk of Lyme disease transmission as a direct result of killing black-legged ticks/deer ticks.

How does Simparica TRIO work?

Simparica TRIO contains a combination of sarolaner, moxidectin, and pyrantel. Sarolaner causes uncontrolled neuromuscular activity in insects, leading to their death. Moxidectin and pyrantel cause paralysis in parasites, leading to their death.

Ingredients
Sarolaner, moxidectin, pyrantel
Key Benefits
Advantages Of Simparica TRIO
  • Easy-to-dose oral parasite treatment for dogs
  • Flavored chews with an acceptable taste
  • Provides triple protection against parasites
  • Prevents heartworm disease
  • Kills adult fleas and prevents flea infestations
  • Treats and controls infestations caused by multiple tick species
  • Helps prevent flea tapeworm infections by eliminating fleas
  • Helps reduce the risk of Lyme infection by killing deer ticks
  • Suitable for dogs aged 8 weeks and older, weighing at least 2.8 pounds
  • Available in different packs for accurate, weight-specific dosing
Directions for Use

Instructions To Use Simparica TRIO

  • Weigh your dog and select the appropriate pack of Simparica TRIO chewable tablets.
  • Administer one chew orally to your dog once a month, with or without food.
  • Ensure your dog consumes the complete dose and that no portion is missed or refused.
  • If a dose is missed, administer Simparica TRIO immediately and resume the regular monthly dosing schedule.
Packaging:
  • Simparica TRIO chews are available in six different sizes for convenient, weight-appropriate dosing.
  • The packs are color-coded for easier identification.

Dosing Schedule:

Dog Weight (lbs.) Pack Color Sarolaner per Tablet (mg) Moxidectin per Tablet (mg) Pyrantel per Tablet (mg) Number of Tablets
2.8 – 5.5 Yellow 3 0.06 12.5 One
5.6 – 11 Purple 6 0.12 25 One
11.1 – 22 Caramel 12 0.24 50 One
22.1 – 44 Blue 24 0.48 100 One
44.1 – 88 Green 48 0.96 200 One
88.1 – 132 Brown 72 1.44 300 One
>132 Administer the appropriate combination of tablets.
Safety
Simparica TRIO Safety Measures
  • This chew is not for human use. Use it only for your dog.
  • Keep out of reach of children.
  • Store Simparica TRIO in a secure location, out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.

Precautions

  • Use Simparica TRIO with caution in dogs with a history of seizures or neurologic disorders.
  • Dogs should be tested for existing heartworm infections before starting treatment. Infected dogs must be treated to remove adult heartworms prior to administering this chew.
  • Consult a veterinarian before using in breeding, pregnant, or lactating dogs.

Storage

  • Store at or below 86°F (30°C).
FAQ

1. Is Simparica TRIO the same as other parasite preventives?

Simparica TRIO is an all-in-one monthly chew that provides comprehensive protection for dogs. This single, convenient chew protects against heartworm disease, fleas, intestinal worms, and six types of ticks.

2. Is Simparica TRIO safe?

Simparica TRIO is a widely prescribed parasite treatment for dogs. It has been demonstrated to be safe for puppies as young as 8 weeks old and weighing at least 2.8 lbs.

3. Can I give Simparica TRIO to my pregnant dog?

The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs. Consult a veterinarian before administering this chew to such dogs.

4. Does Simparica TRIO prevent Lyme disease?

Simparica TRIO helps reduce the risk of Lyme infection as a direct result of killing black-legged ticks (deer ticks).

5. What should I do if my dog spits out the Simparica TRIO dose?

If your dog vomits or spits out the dose, administer a new dose. Consult your veterinarian for further guidance if necessary.

6. Does Simparica TRIO treat tapeworms?

Simparica TRIO helps prevent flea tapeworm infections as a direct result of killing fleas.

7. What if I miss a Simparica TRIO dose?

If a dose is missed, administer a new dose immediately and then resume the regular monthly dosing schedule.

8. How fast does Simparica TRIO work on fleas and ticks?

Simparica TRIO begins killing deer ticks within 8 hours and fleas within 4 hours of administration.

9. Where can I get Simparica TRIO?

Simparica TRIO is widely available online and through veterinary providers, making it easy to maintain your pet’s parasite protection.

Customer Review
Overall Rating

Star4.7/5

454 reviews
454 reviews
Sort By:
Paul
Order

Great value for the money.

Feb 26, 2026
Lori
Simparica Trio

The Simparica Trio was delivered in a timely manner at about half the cost of domestic providers for the same product. Thank you.

Feb 24, 2026
John
Easy, Easy, Easy

First time user. The process worked as advertised. I had an after-my-order question and customer service was spot on when I called them. The product was exactly as ordered. The price was half that of what my vet could offer.

Feb 24, 2026
Barbara
Another problem free order

Thank you... great expiration dates, fast shipping considering international... not issues...thank you!!

Feb 24, 2026
Phyllis
great product at a discount

and the shipping was fast

Feb 24, 2026
Have A Question?
Question:
Q:

How does it take to be shipped after placing an order?

Answer:
A:

All orders are processed and dispatched on the same day. Orders received on a public holiday or during the weekends are dispatched on the next working day.

Feb 13, 2026
Question:
Q:

allergy pills for pups

Answer:
A:

You can use Ecovet Eco-Allergy Liquid. This oral liquid concentration helps reduce the sensitivity to allergens and provides general support for the treatment of allergies.

Nov 11, 2025
Question:
Q:

What is the diameter of the chew, I may have to force it down my pups throat.

Answer:
A:

If your dog cannot take the chew as a whole, you can hide it in their favorite food.

Nov 11, 2025
Question:
Q:

What is the flavor? Chicken? Beef? My dog cannot eat chicken

Answer:
A:

Simparica Trio comes in a palatable pork liver-flavor.

Jan 27, 2025
Question:
Q:

How often is it given

Answer:
A:

Simparica Trio is a monthly treatment and should be administered to dogs once every month.

Jan 07, 2025
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