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Simparica TRIO for Dogs

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(471)

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$27.63

Simparica TRIO for Dogs 2.8-5.5 lbs (Yellow)

Pack
Qty
Price
You Pay
 
3 Doses
$34.54
$27.63
6 Doses
$67.21
$53.77

Simparica TRIO for Dogs 5.6-11 lbs (Purple)

Pack
Qty
Price
You Pay
 
3 Doses
$35.53
$28.42
6 Doses
$68.20
$54.56
12 Doses
$133.54
$106.83

Simparica TRIO for Dogs 11.1-22 lbs (Caramel)

Pack
Qty
Price
You Pay
 
3 Doses
$37.51
$30.01
6 Doses
$72.16
$57.73
12 Doses
$138.49
$110.79

Simparica TRIO for Dogs 22.1-44 lbs (Blue)

Pack
Qty
Price
You Pay
 
3 Doses
$44.44
$35.55
6 Doses
$85.03
$68.02
12 Doses
$166.21
$132.97

Simparica TRIO for Dogs 44.1-88 lbs (Green)

Pack
Qty
Price
You Pay
 
3 Doses
$58.30
$46.64
6 Doses
$111.76
$89.41
12 Doses
$217.69
$174.15

Simparica TRIO for Dogs above 88 lbs (Brown)

Pack
Qty
Price
You Pay
 
3 Doses
$71.17
$56.94
6 Doses
$138.49
$110.79
12 Doses
$273.13
$218.50
  • Information
  • Key Benefits
  • Directions for Use
  • Safety
  • FAQ
Information

Simparica TRIO Chews for Dogs

Simparica TRIO is a widely prescribed, broad-spectrum parasite preventive for your dog. According to Zoetis, this versatile treatment has protected million of dogs so far. It is flavored to make the dosing easier; dogs love the taste and readily accept this chew. This delicious chew provides triple protection to your dog against heartworm disease, ticks & fleas, and worms (roundworms and hookworms). This monthly treatment is suitable for dogs aged 8 weeks and above, and weighing at least 2.8 pounds. Simparica TRIO is available in different flavored tablet sizes for accurate dosage in dogs of different weights.

Simparica TRIO coverage

Simparica TRIO chews are to be administered at monthly intervals. You may start your dog’s treatment with this chew at any time of the year. When administered as recommended, Simparica TRIO prevents heartworm disease caused by Dirofilaria immitis, and treats and controls roundworm and hookworm infections. It kills adult fleas, prevents flea infestations, and treats and controls tick infestations with lone star tick, Gulf Coast tick, American dog tick, black-legged tick, brown dog tick, and Asian longhorned tick.

Additionally, this all-inclusive treatment helps prevent flea tapeworm infections as a direct result of killing fleas, and helps reduce the risk of Lyme disease transmission as a direct result of killing black-legged ticks/deer ticks.

How does Simparica TRIO work?

Simparica TRIO contains a combination of sarolaner, moxidectin, and pyrantel. Sarolaner causes uncontrolled neuromuscular activity in insects, leading to their death. Moxidectin and pyrantel cause paralysis in parasites, leading to their death.

Key Benefits
Advantages Of Simparica TRIO
  • Easy-to-dose, oral parasite treatment for dogs
  • Flavored chews, offer acceptable taste
  • Provides triple protection against parasites
  • Prevents heartworm disease
  • Kills adult fleas & prevents flea infestations
  • Treats and controls infestations from multiple species of ticks
  • Helps prevent flea tapeworm infections as a direct result of killing fleas
  • Helps reduce the risk of Lyme infection as a direct result of killing deer ticks
  • Suitable for dogs aged 8 weeks and above, and weighing at least 2.8 pounds
  • Available in different packs for accurate weight-specific dosage
Directions for Use

Instructions To Use Simparica TRIO

Directions for use:

  • Weigh your dog and get the suitable pack of Simparica TRIO chewable tablets.
  • Give the chew orally to your dog once a month. Administer the chew with or without food.
  • Ensure that your dog consumes the complete dose, and that any part of the dose is not missed or refused.
  • If a dose is missed, give Simparica TRIO immediately and resume monthly dosing.

Packaging:

  • Simparica TRIO Chews are available in six different sizes for convenient, weight-appropriate dosage.
  • The packs are color-coded for easier identification.

Dosing schedule:

Dog weight (lbs.) Pack color Sarolaner per tablet (mg) Moxidectin per tablet (mg) Pyrantel per tablet (mg) Number of tablets administered
2.8 – 5.5 Yellow 3 0.06 12.5 One
5.6 to 11 Purple 6 0.12 25 One
11.1 to 22 Caramel 12 0.24 50 One
22.1 to 44 Blue 24 0.48 100 One
44.1 to 88 Green 48 0.96 200 One
88.1 to 132 Brown 72 1.44 300 One
>132 Administer the appropriate combination of tablets
Safety
Simparica TRIO Safety Measures
  • This chew is not for human use. Use it only for your dog.
  • It should be kept out of reach of children.
  • Store Simparica TRIO in a secure location, out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.

Precautions

  • Use Simparica TRIO with caution in dogs with a history of seizures or neurologic disorders.
  • Dogs should be tested for existing heartworm infections, and infected dogs should be treated to remove adult heartworms, before administering this chew.
  • Consult a veterinarian before using it in breeding, pregnant, or lactating dogs.

Storage

  • Store at or below 86°F (30°C).
FAQ

Frequently Asked Questions

1. Is Simparica TRIO the same as other parasite preventives?

Simparica TRIO is an all-in-one chew that provides comprehensive protection to dogs. This single, convenient monthly chew protects dogs against heartworm disease, fleas, intestinal worms, and 6 types of ticks.

2. Is Simparica TRIO safe?

Simparica TRIO is a widely prescribed parasite treatment for dogs. It has been demonstrated to be safe for dogs as young as 8 weeks old and weighing as little as 2.8 lbs.

3. Can I give Simparica TRIO to my pregnant dog?

Safe use of Simparica TRIO has not been evaluated in breeding, pregnant or lactating dogs. Consult a veterinarian before using this chew in such pets.

4. Does Simparica TRIO prevent Lyme disease?

Simparica TRIO helps prevent Lyme infection as a direct result of killing black-legged ticks/deer ticks.

5. What to do if my dog spits out the Simparica TRIO dose?

If a dog vomits or spits out the dose, a new dose should be given. Check with your veterinarian for guidance, if required.

6. Does Simparica TRIO treat tapeworms?

Simparica TRIO prevents flea tapeworm infections as a direct result of killing fleas.

7. What if I miss a Simparica TRIO dose?

If a dose is missed, a new dose should be administered immediately. Then, you may continue on the prescribed monthly dosing schedule.

8. How fast does Simparica TRIO work on fleas and ticks?

Simparica TRIO’s quick-action formula starts to kill deer ticks within 8 hours and fleas within 4 hours.

9. Where can I get Simparica TRIO?

Simparica TRIO is widely available. You can shop for it online and easily ensure your pet’s parasite protection.

Customer Review
Overall Rating

Star4.7/5

471 reviews
471 reviews
Sort By:
Sophia
Life Simplified

Finally, one chew that handles everything—no more juggling multiple pills.

May 16, 2026
Bella
All-in-One Ease

Such a convenient chew for heartworm, flea, and tick protection combined!

May 09, 2026
Gary
Simpatico Trio

Product came quicker than expected and was exactly as advertised. Our dogs have begun their treatments are doing great. Thank you.

May 02, 2026
Bella
All-in-One

Covers everything we need. Very convenient and reliable.

May 02, 2026
Mary
Complete 3-in-1 Protection

I love that this covers heartworm, fleas, and ticks in one dose.

May 02, 2026
Have A Question?
Question:
Q:

How long does standard shipping take

Answer:
A:

Most of our orders are delivered within 10-15 working days.

May 19, 2026
Question:
Q:

Are there any current promotions

Answer:
A:

Currently, you will be able to receive 20% discount on all purchases without the need for a discount coupon.

May 19, 2026
Question:
Q:

Are there any promo codes for simparica 3

Answer:
A:

Currently, we are providing 20% discount on all products.

Apr 17, 2026
Question:
Q:

Does Simparica trio also cover heartworm as well as flea and tick?

Answer:
A:

Yes, Simparica Trio effectively prevents heartworm disease along with protecting against fleas and ticks.

Mar 13, 2026
Question:
Q:

How does it take to be shipped after placing an order?

Answer:
A:

All orders are processed and dispatched on the same day. Orders received on a public holiday or during the weekends are dispatched on the next working day.

Feb 13, 2026
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